![]() Bacterial and mycology cultures demonstrate the presence of specific beneficial and pathological organisms.GI Effects assesses a set of 24 genera/species that map to 7 major phyla.More than 95% of commensal gut organisms are anaerobic and are difficult to recover by traditional (aerobic) culture techniques.Commensal Bacteria demonstrate the composition and relative abundance of gut organisms.Metabolic indicators, including short-chain fatty acids and beta-glucuronidase, demonstrate specific and vital metabolic functions performed by the microbiota.Fecal Secretory IgA is a marker of gut secretory immunity and barrier function.Eosinophil Protein X is a marker of eosinophil-driven inflammation and allergic response.Produced in abundance at sites of inflammation, this biomarker has been proven clinically useful in differentiating between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). Calprotectin is a marker of neutrophil-driven inflammation.Fecal Fat is a marker of fat breakdown and absorption. ![]() Products of Protein Breakdown are markers of undigested protein reaching the colon.Pancreatic Elastase-1 is a marker of exocrine pancreatic function.The biomarkers from the GI Effects Comprehensive Profile are reported using the DIG framework, providing key clinical information for three main gastrointestinal functional areas: The GI Effects Comprehensive Stool Profile Biomarkers 1,2 The diverse metabolic activities of the microbiome ultimately impact the human host, and the activities of the human host ultimately affect the health of their microbiome. A sizeable volume of research associates a dysbiotic, or imbalanced gut microbiome with multiple disease states both within and outside of the GI tract. Gut microbes are codependent with one another and with their human host, and the health of one affects the other. 3,4 In addition, Genova’s GI Effects test can be used to evaluate patients with a clinical history that suggests a gastrointestinal infection or dysbiosis. This stool analysis utilizes biomarkers such as Calprotectin to differentiate between Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS). The GI Effects Comprehensive Stool Profile can reveal important information about the root cause of many common gastrointestinal symptoms such as gas, bloating, indigestion, abdominal pain, diarrhea, and constipation. When Should the GI Effects Comprehensive Stool Profile Be Considered?
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